Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Captopril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 7/20 | 1.00 |
| ▸ | REN | P00797 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | LTA4H | P09960 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PEPD | P12955 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Captopril SCHEMBL7983782 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL675797 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2444049 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL1913521 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL4 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2422871 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2444053 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL2786691 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL5556542 | 0.98 | ACE (0.97) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL2489188 | 0.98 | ACE (0.97) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030100770-A1 | Such as 1-((S)-3-mercapto-2-methyl-propionyl)-(R)-pyrrol-idine-2-carboxylic acid for treating diseases associated with amyloidosis (Alzheimer's disease, diabetes, and familial amyloid polyneuropathy) | PENTRAXIN THERAPEUTICS LTD. (GB) | 2003-05-29 | — | — | US | claimed |
| EP-0915088-A1 | D-Proline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-12 | — | — | EP | claimed |
| EP-3681504-B1 | METHODS OF DETECTION USING X-RAY FLUORESCENCE | ICAGEN INC (US) | 2023-08-23 | — | — | EP | disclosed |
| US-20230172885-A1 | THIOL-CONTAINING COMPOUNDS FOR USE IN TREATING CORONAVIRUS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-08 | — | — | US | disclosed |
| US-20230172885-A1 | THIOL-CONTAINING COMPOUNDS FOR USE IN TREATING CORONAVIRUS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-08 | — | — | US | disclosed |
| CN-114634891-B | Bacillus bailii ZH3 and application thereof | 厦门萤星海科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| US-11649222-B2 | Compounds | UNIVERSITETET I OSLO (NO) | 2023-05-16 | — | — | US | disclosed |
| US-11649222-B2 | Compounds | UNIVERSITETET I OSLO (NO) | 2023-05-16 | — | — | US | disclosed |
| US-11573224-B2 | Methods of detection using X-ray fluorescence | ICAGEN, LLC (US) | 2023-02-07 | — | — | US | disclosed |
| WO-2023284611-A1 | ROS-RESPONSIVE CAPTOPRIL-CINNAMALDEHYDE PRODRUGS AND COMPOSITIONS AND METHODS THEREOF | THE UNIVERSITY OF HONG KONG (CN) | 2023-01-19 | — | — | WO | disclosed |
| CN-114634891-A | Bacillus belgii ZH3 and application thereof | 厦门萤星海科技有限公司 | 2022-06-17 | — | — | CN | disclosed |
| US-6103910-A | FOR TREATMENT OF DISEASES ASSOCIATED WITH AMYLOIDOSIS, SUCH AS ALZHEIMER'S DISEASE, DIABETES MELLITUS, FAMILIAL AMYLOID POLYNEUROPATHY, SCRAPIE, AND KREUZFELD-JACOB DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0915088-A1 | D-Proline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-12 | — | — | EP | disclosed |
| US-5571834-A | HYPOTENSIVE AGENTS | ZAMBON GROUP S.P.A. (IT) | 1996-11-05 | — | — | US | disclosed |
| US-5304570-A | Ibopamine or salt and enzyme inhibitor (S,S),-N-(3-(4-methoxybenzoylthio)-2-methyl-propionyl)-proline) | ZAMBON GROUP S.P.A. (IT) | 1994-04-19 | — | — | US | disclosed |
| EP-0351017-B1 | Pharmaceutical composition useful for the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1994-01-19 | — | — | EP | disclosed |
| EP-0351017-A2 | Pharmaceutical composition useful for the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1990-01-17 | — | — | EP | disclosed |
| EP-0037231-B1 | SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACIDS | WARNER-LAMBERT COMPANY (US) | 1987-01-28 | — | — | EP | disclosed |
| US-4442090-A | ACYLATED AMINO ACID | KYOTO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1984-04-10 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100770-A1 | Such as 1-((S)-3-mercapto-2-methyl-propionyl)-(R)-pyrrol-idine-2-carboxylic acid for treating diseases associated with amyloidosis (Alzheimer's disease, diabetes, and familial amyloid polyneuropathy) | PSEN1, PSEN2, IAPP | ACE 1460/4885REN 166/4885KDM4E 1764/4885 |
| US-20230172885-A1 | THIOL-CONTAINING COMPOUNDS FOR USE IN TREATING CORONAVIRUS | CTH, SARS1, CBS | ACE 4/4885REN 392/4885KDM4E 3990/4885 |
| US-11649222-B2 | Compounds | SLC30A6, SLC39A11, SLC39A3 | ACE 380/4885REN 1665/4885KDM4E 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.