Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Captopril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 7/20 | 1.00 |
| ▸ | REN | P00797 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | LTA4H | P09960 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PEPD | P12955 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Captopril SCHEMBL7983782 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2444049 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL678794 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL1913521 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL4 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2422871 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2444053 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL2786691 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL5556542 | 0.98 | ACE (0.97) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL2489188 | 0.98 | ACE (0.97) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 533 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117757578-A | Semiconductor chip cleaning solution containing amino acid, preparation method and application thereof | 江苏奥首材料科技有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-107684559-B | Gold cluster-containing substance and preparation method and application thereof | 深圳深见医药科技有限公司 | 2023-08-15 | — | — | CN | claimed |
| CN-112526056-B | Separation and detection method of captopril and diastereoisomer thereof | 江苏晶立信医药科技有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-114558029-A | Copper cluster, thymine modified hyaluronic acid and poly-copper cluster, and preparation method and application thereof | 武汉广行科学研究有限公司 | 2022-05-31 | — | — | CN | claimed |
| CN-109939243-B | Copper cluster, thymine modified hyaluronic acid and poly-copper cluster, and preparation method and application thereof | 武汉广行科学研究有限公司 | 2022-03-15 | — | — | CN | claimed |
| CN-107684560-B | Application of substance containing gold clusters in preparation of medicine for preventing and treating Alzheimer disease | 深圳深见医药科技有限公司 | 2021-05-11 | — | — | CN | claimed |
| CN-107693538-B | Application of substance containing gold clusters in preparation of drug for preventing and treating Parkinson's disease | 深圳深见医药科技有限公司 | 2021-05-11 | — | — | CN | claimed |
| CN-112526056-A | Separation and detection method of captopril and diastereoisomer thereof | 江苏晶立信医药科技有限公司 | 2021-03-19 | — | — | CN | claimed |
| CN-111848471-A | Application of substance containing gold clusters in preparation of drug for preventing and treating Parkinson's disease | 深圳深见医药科技有限公司 | 2020-10-30 | — | — | CN | claimed |
| CN-111848472-A | Application of substance containing gold clusters in preparation of medicine for preventing and treating Alzheimer disease | 深圳深见医药科技有限公司 | 2020-10-30 | — | — | CN | claimed |
| EP-0163237-A2 | Di- and tri-peptidal renin inhibitors | MERCK & CO. INC. (US) | 1985-12-04 | — | — | EP | claimed |
| EP-0160307-A2 | Angiotensin converting enzyme inhibitors useful in the treatment of renal diseases | MERCK & CO. INC. (US) | 1985-11-06 | — | — | EP | claimed |
| EP-0157409-A2 | Renin inhibitors containing 2-substituted statine | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | claimed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0156322-A2 | Renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0129189-A2 | Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4332726-A | Purification of mercaptoacyl amino acids | E. R. SQUIBB & SONS, INC. (US) | 1982-06-01 | — | — | US | claimed |
| US-4307099-A | Reaction products of pyrazolo[1,5-c]quinazoline derivatives and proline derivatives and methods for reducing blood pressure while inhibiting allergic reactions with them | E. R. SQUIBB & SONS, INC. (US) | 1981-12-22 | — | — | US | claimed |
| EP-0038541-A1 | Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same | MERCK & CO. INC. (US) | 1981-10-28 | — | — | EP | claimed |
| US-4217347-A | MERCAPTOALKYL ALKANOYLPROLINES AND A DIURETIC | E. R. SQUIBB & SONS, INC. (US) | 1980-08-12 | — | — | US | claimed |