Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937853 | 1.00 | RIPK1 (0.47) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| SCHEMBL1801302 | 1.00 | RIPK1 (0.47) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1800383 | 0.99 | RIPK1 (0.47) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| SCHEMBL2937011 | 0.94 | CXCR3 (0.46) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| SCHEMBL2934126 | 0.94 | CXCR3 (0.46) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| SCHEMBL1800862 | 0.94 | CXCR3 (0.46) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1801174 | 0.94 | CXCR3 (0.45) | RIPK1CCR8KCNH2ALDH1A1LMNA | |
| SCHEMBL2933989 | 0.92 | CYP2D6 (0.54) | CCR8KCNH2ALDH1A1CXCR3MGLL | |
| SCHEMBL1801247 | 0.92 | CYP2D6 (0.54) | CCR8KCNH2ALDH1A1CXCR3MGLL | |
| SCHEMBL2933986 | 0.92 | CYP2D6 (0.54) | CCR8KCNH2ALDH1A1CXCR3MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095402-A9 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2009-06-11 | — | — | WO | disclosed |
| EP-1730147-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095402-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | disclosed |