⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32683790 | 0.74 | — | — | |
| SCHEMBL16138546 | 0.74 | — | — | |
| SCHEMBL16791110 | 0.71 | CRBN (0.35) | — | |
| SCHEMBL16268205 | 0.70 | — | — | |
| SCHEMBL17323621 | 0.70 | TOP2A (0.32) | — | |
| SCHEMBL20390537 | 0.67 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL12679289 | 0.67 | TOP2A (0.33) | — | |
| SCHEMBL30832410 | 0.67 | LMNA (0.38) | — | |
| SCHEMBL21910792 | 0.65 | PDK2 (0.52) | — | |
| SCHEMBL14446948 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260069602-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | ACONCAGUA BIO INC (US) | 2026-03-12 | — | — | US | disclosed |
| WO-2024067709-A1 | PYRIDINYLAMIDE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND MEDICAL USE THEREOF | 苏州阿尔脉生物科技有限公司 | 2024-04-04 | — | — | WO | disclosed |
| US-20230399423-A1 | POLYMERIC DISINFECTANTS AND USES THEREOF | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2023-12-14 | — | — | US | disclosed |
| EP-3344624-B1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI INC (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-106905215-B | Process for preparing 1-H-pyrrolidine-2, 4-dione derivatives | 拜耳知识产权有限责任公司 | 2021-10-01 | — | — | CN | disclosed |
| US-20210047319-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-02-18 | — | — | US | disclosed |
| US-10781204-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-09-22 | — | — | US | disclosed |
| EP-3372580-B1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2020-07-22 | — | — | EP | disclosed |
| EP-3372580-A1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2018-09-12 | — | — | EP | disclosed |
| US-10023571-B2 | TYK2 inhibitors and uses thereof | Nimbus Lakshimi, Inc. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20140235446-A1 | 2,3-DIPHENYL-VALERONITRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES AND PLANT GROWTH REGULATORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-08-21 | — | — | US | disclosed |
| US-8791111-B2 | Piperidine and piperazine derivatives | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8754097-B2 | Piperidine and piperazine derivatives | MERCK PATENT GMBH (DE) | 2014-06-17 | — | — | US | disclosed |
| EP-2668158-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2013-12-04 | — | — | EP | disclosed |
| US-20120316162-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-13 | — | — | US | disclosed |
| WO-2012101047-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2012-08-02 | — | — | WO | disclosed |
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2012-07-26 | — | — | US | disclosed |
| WO-2009071888-A1 | PYRROLOTHIAZOLES AS PI3-KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2002014292-A1 | METHOD FOR PRODUCING 5, 5-DIMETHYLOXAZOLIDINE-2, 4-DIONE | SHOWA DENKO K.K. (JP) | 2002-02-21 | — | — | WO | disclosed |
| WO-1994001401-A1 | HERBICIDAL AND INSECTICIDAL 3-BENZOYL-PYRROLIDIN-2,4-DIONE DERIVATES | BAYER AKTIENGESELLSCHAFT (DE) | 1994-01-20 | — | — | WO | disclosed |