Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002539 | 0.88 | HTR1F (0.38) | MAPK8SSTR5HTR1FSLC6A2SLC6A4 | |
| SCHEMBL3997569 | 0.88 | HTR1F (0.39) | MAPK8HTR1FSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3998722 | 0.88 | HTR1F (0.38) | MAPK8SSTR5HTR1FSLC6A2SLC6A4 | |
| SCHEMBL3998025 | 0.86 | SLC6A2 (0.37) | MAPK8SSTR5HRH1HTR1FSLC6A2 | |
| SCHEMBL4004209 | 0.85 | TACR1 (0.38) | MAPK8SSTR5HRH1HTR1FSLC6A2 | |
| SCHEMBL4003842 | 0.83 | SSTR5 (0.40) | SSTR5KCNH2 | |
| SCHEMBL4002646 | 0.78 | ALOX15 (0.42) | SSTR5HTR1FSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3996199 | 0.77 | HTR2A (0.37) | HTR1FSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4705441 | 0.76 | SLC6A2 (0.40) | SSTR5HRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594292 | 0.76 | SSTR5 (0.39) | SSTR5HRH1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | disclosed |