Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18711468 | 0.87 | L3MBTL1 (0.38) | HTR2CHTR2BHTR2AGLASPR | |
| SCHEMBL13890356 | 0.82 | PDE10A (0.36) | KMT2AHTR2CHTR2BHTR2AGSK3B | |
| SCHEMBL3999675 | 0.80 | GSK3B (0.43) | MAPK1CDK2CDK9HTTGSK3B | |
| SCHEMBL6517226 | 0.77 | SPR (0.38) | SPRKCNN3PDE10A | |
| SCHEMBL4004452 | 0.75 | HAVCR2 (0.39) | HTR2CHTR2BCDK9GSK3BSPR | |
| SCHEMBL15739828 | 0.71 | PDE10A (0.38) | HTR2CHTR2BHTR2ACDK2SPR | |
| SCHEMBL18701564 | 0.71 | USP2 (0.41) | HTR2CHTR2BHTR2AMAPK1CDK2 | |
| SCHEMBL1487918 | 0.71 | KMT2A (0.36) | POLBKMT2AHTTHPGDKDM4E | |
| SCHEMBL13875162 | 0.68 | PDE10A (0.35) | HTR2CHTR2BHTR2ASPRPDE10A | |
| SCHEMBL9422938 | 0.67 | GSK3B (0.44) | KDM4CMAPK1GSK3BKDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074677-A2 | PYRAZOLOTRIAZINES | 4SC AG (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |