Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007838 | 0.87 | CHRNB4 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4JAK2 | |
| SCHEMBL4007789 | 0.76 | CHRNB4 (0.52) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4013740 | 0.76 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4013764 | 0.74 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4005115 | 0.73 | CHRNB2 (0.49) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4012993 | 0.68 | CHRNB4 (0.52) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL13768036 | 0.68 | ABL1 (0.38) | CHRNB4CHRNA3 | |
| SCHEMBL4009078 | 0.65 | CHRNB4 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4005919 | 0.65 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4009077 | 0.65 | CHRNB2 (0.49) | CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081246-A2 | BICYCLIC DIAMINES AS NICOTINIC RECEPTOR AGONISTS | PFIZER INC. (US) | 2009-07-02 | — | — | WO | claimed |
| WO-2009081246-A2 | BICYCLIC DIAMINES AS NICOTINIC RECEPTOR AGONISTS | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |