Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000400 | 0.81 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL4003868 | 0.79 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL4002978 | 0.79 | HCRTR1 (0.59) | HCRTR1HCRTR2 | |
| SCHEMBL1596940 | 0.76 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL4003844 | 0.76 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL1398907 | 0.74 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL3038233 | 0.69 | LMNA (0.41) | HCRTR1HCRTR2LMNA | |
| SCHEMBL3641723 | 0.69 | LMNA (0.41) | HCRTR1HCRTR2LMNA | |
| SCHEMBL3638225 | 0.69 | LMNA (0.40) | HCRTR1HCRTR2LMNA | |
| SCHEMBL3053184 | 0.69 | LMNA (0.40) | HCRTR1HCRTR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069332-A2 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008020405-A2 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-02-21 | — | — | WO | disclosed |