Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | TACR1 | P25103 | 3/20 | 0.62 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17266198 | 0.81 | MEN1 (0.67) | MEN1KMT2ARIPK1SCD5HPGD | |
| SCHEMBL6417274 | 0.77 | RIPK1 (0.64) | MEN1KMT2ARIPK1SCD5HPGD | |
| SCHEMBL9112410 | 0.75 | TACR1 (0.70) | MEN1KMT2ATDP1TACR1CRHBP | |
| SCHEMBL29565351 | 0.75 | RIPK1 (0.65) | MEN1KMT2ARIPK1SCD5HPGD | |
| SCHEMBL13738659 | 0.74 | RIPK1 (0.72) | MEN1KMT2ARIPK1SCD5HPGD | |
| SCHEMBL254915 | 0.73 | AOC3 (0.58) | MEN1KMT2ARIPK1SCD5FOLH1 | |
| SCHEMBL7882340 | 0.73 | MEN1 (0.57) | MEN1KMT2ATDP1TACR1RIPK1 | |
| SCHEMBL6412442 | 0.72 | MEN1 (0.56) | MEN1KMT2ARIPK1SCD5HPGD | |
| SCHEMBL6412445 | 0.72 | MEN1 (0.56) | MEN1KMT2ARIPK1SCD5HPGD | |
| SCHEMBL8572659 | 0.72 | KDM4E (0.61) | MEN1KMT2ATDP1TACR1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041071-A2 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | Kinex Pharmaceuticals, LLC (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008002676-A9 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS LLC (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008002676-A2 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2008-01-03 | — | — | WO | disclosed |