Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9114068 | 0.86 | TACR1 (0.64) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL9114442 | 0.82 | TACR1 (1.00) | TACR1MEN1KMT2ATDP1MAPK1 | |
| SCHEMBL27416261 | 0.79 | TACR1 (0.57) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL4004186 | 0.75 | MEN1 (1.00) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL9114494 | 0.74 | TACR1 (0.64) | TACR1MEN1KMT2ATDP1 | |
| SCHEMBL1573474 | 0.74 | TACR1 (0.51) | TACR1MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL9113000 | 0.73 | TACR1 (0.69) | TACR1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL9116053 | 0.72 | TACR1 (0.62) | TACR1MEN1KMT2ATDP1 | |
| SCHEMBL9114531 | 0.72 | TACR1 (0.77) | TACR1MEN1KMT2ATDP1 | |
| SCHEMBL9114062 | 0.72 | TACR1 (0.62) | TACR1MEN1KMT2ATDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995011880-A1 | SUBSTITUTED AMIDES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-05-04 | — | — | WO | claimed |
| WO-1995011880-A1 | SUBSTITUTED AMIDES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-05-04 | — | — | WO | disclosed |