Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019694 | 0.92 | CYP3A4 (0.35) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL13688375 | 0.86 | — | — | |
| SCHEMBL13688383 | 0.85 | THRB (0.41) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL13688355 | 0.83 | CYP3A4 (0.37) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL13688390 | 0.83 | TSHR (0.40) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL14019717 | 0.83 | THRB (0.46) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL13688368 | 0.82 | NAAA (0.42) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL13688379 | 0.82 | CYP3A4 (0.32) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL13688359 | 0.82 | EPHX2 (0.33) | TSHRCYP3A4ABCB11LMNACYP1A2 | |
| SCHEMBL14019721 | 0.82 | CYP3A4 (0.35) | TSHRCYP3A4ABCB11LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585901-B2 | Polymerizable bicyclic cyclopropane derivatives and their use for the preparation of dental materials | IVOCLAR VIVADENT AG (LI) | 2009-09-08 | — | — | US | disclosed |
| US-7585901-B2 | Polymerizable bicyclic cyclopropane derivatives and their use for the preparation of dental materials | IVOCLAR VIVADENT AG (LI) | 2009-09-08 | — | — | US | disclosed |
| US-7585901-B2 | Polymerizable bicyclic cyclopropane derivatives and their use for the preparation of dental materials | IVOCLAR VIVADENT AG (LI) | 2009-09-08 | — | — | US | disclosed |
| US-7365222-B2 | 1,1-Disubstituted 2-vinylcyclopropanes; free radical polymerizable monomers | IVOCLAR VIVADENT AG (LI) | 2008-04-29 | — | — | US | disclosed |
| US-7365222-B2 | 1,1-Disubstituted 2-vinylcyclopropanes; free radical polymerizable monomers | IVOCLAR VIVADENT AG (LI) | 2008-04-29 | — | — | US | disclosed |
| US-7365222-B2 | 1,1-Disubstituted 2-vinylcyclopropanes; free radical polymerizable monomers | IVOCLAR VIVADENT AG (LI) | 2008-04-29 | — | — | US | disclosed |
| US-20070232719-A1 | POLYMERIZABLE BICYCLIC CYCLOPROPANE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF DENTAL MATERIALS | IVOCLAR VIVADENT AG (LI) | 2007-10-04 | — | — | US | disclosed |
| US-20070232719-A1 | POLYMERIZABLE BICYCLIC CYCLOPROPANE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF DENTAL MATERIALS | IVOCLAR VIVADENT AG (LI) | 2007-10-04 | — | — | US | disclosed |
| US-20070232719-A1 | POLYMERIZABLE BICYCLIC CYCLOPROPANE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF DENTAL MATERIALS | IVOCLAR VIVADENT AG (LI) | 2007-10-04 | — | — | US | disclosed |
| EP-1413569-B1 | Bicyclic cyclopropane derivatives capable of polymerisation and their use in the preparation of dental materials | IVOCLAR VIVADENT AG (LI) | 2006-12-13 | — | — | EP | disclosed |
| EP-1413569-A1 | Bicyclic cyclopropane derivatives capable of polymerisation and their use in the preparation of dental materials | Ivoclar Vivadent AG (LI) | 2004-04-28 | — | — | EP | disclosed |
| US-20040077882-A1 | Polymerizable bicyclic cyclopropane derivatives and their use for the preparation of dental materials | IVOCLAR VIVADENT AG (LI) | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232719-A1 | POLYMERIZABLE BICYCLIC CYCLOPROPANE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF DENTAL MATERIALS | CBR1, CYP8B1, OXER1 | TSHR 2827/4885CYP3A4 179/4885ABCB11 719/4885 |
| US-20040077882-A1 | Polymerizable bicyclic cyclopropane derivatives and their use for the preparation of dental materials | SCO2, CBR1, CORO1C | TSHR 3175/4885CYP3A4 306/4885ABCB11 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.