SCHEMBL4004572

SCHEMBL4004572

C=Cc1ccc(S(=O)(=O)Nc2ccc3[nH]cc(CN4CCN(C)CC4)c3c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 19/20 0.54
MPO P05164 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5659589 0.83 HTR6 (0.53) HTR6MPO
SCHEMBL4970421 0.78 HTR6 (0.50) HTR6MPO
SCHEMBL3147363 0.77 HTR6 (0.52) HTR6MPO
SCHEMBL3147357 0.77 HTR6 (0.52) HTR6MPO
SCHEMBL3323841 0.77 HTR6 (0.74) HTR6MPO
SCHEMBL3138627 0.76 HTR6 (0.55) HTR6MPO
SCHEMBL3138888 0.75 HTR6 (0.86) HTR6MPO
SCHEMBL4969952 0.74 HTR6 (0.53) HTR6MPO
SCHEMBL3147165 0.73 HTR6 (0.77) HTR6
SCHEMBL28805276 0.72 HTR6 (0.62) HTR6MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1660131-B1 ACTIVE SUBSTANCE COMBINATION COMPRISING A COMPOUND WITH NPY RECEPTOR AFFINITY AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY ESTEVE LABOR DR (ES) 2009-06-24 EP disclosed