Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.62 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.62 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400598 | 0.90 | SRD5A2 (0.61) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 | |
| SCHEMBL401103 | 0.86 | SRD5A2 (0.59) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 | |
| SCHEMBL15197141 | 0.85 | SRD5A2 (0.65) | SRD5A2NR4A2NPC1MAOBPTPN1 | |
| SCHEMBL9756579 | 0.84 | PKM (0.54) | SRD5A2RAB9AMAOBPARP10ALDH1A1 | |
| SCHEMBL3232949 | 0.84 | SRD5A2 (0.90) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 | |
| SCHEMBL4000884 | 0.84 | PTGES (0.71) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 | |
| SCHEMBL14392083 | 0.83 | PPARG (0.64) | SRD5A2SMN1; SMN2RAB9AALDH1A1HTT | |
| SCHEMBL10784972 | 0.83 | SRD5A2 (0.77) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 | |
| SCHEMBL402300 | 0.82 | SRD5A2 (0.87) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 | |
| SCHEMBL14672502 | 0.82 | NPC1 (0.54) | SRD5A2NR4A2NR4A1NR4A3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9061981-B2 | Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta | ACADIA PHARMACEUTICALS INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061981-B2 | Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta | ACADIA PHARMACEUTICALS INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061981-B2 | Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta | ACADIA PHARMACEUTICALS INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140275284-A1 | DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA | ACADIA PHARMACEUTICALS INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275284-A1 | DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA | ACADIA PHARMACEUTICALS INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275284-A1 | DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA | ACADIA PHARMACEUTICALS INC. (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2014125121-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014125121-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2014-08-21 | — | — | WO | disclosed |
| EP-2739600-A1 | DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA | Acadia Pharmaceuticals Inc. (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2200994-B1 | CONDENSED COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARM INC (US) | 2014-01-22 | — | — | EP | disclosed |
| WO-2013017619-A1 | DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA | ACADIA PHARMACEUTICALS INC. (US) | 2013-02-07 | — | — | WO | disclosed |
| EP-2554532-A1 | Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta | Acadia Pharmaceuticals Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| EP-2554532-A1 | Diphenyl substituted cyclohexane derivatives, useful as modulators of the estrogen receptors beta | Acadia Pharmaceuticals Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| US-20120088825-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-8101651-B2 | Compounds with activity at estrogen receptors | ACADIA PHARMACEUTICALS INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101651-B2 | Compounds with activity at estrogen receptors | ACADIA PHARMACEUTICALS INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2200994-A1 | CONDENSED COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | Acadia Pharmaceuticals Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20090131510-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. | 2009-05-21 | — | — | US | disclosed |
| US-20090131510-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. | 2009-05-21 | — | — | US | disclosed |
| WO-2009055734-A1 | CONDENSED COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088825-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ESRRB, ESR2, ESRRA | SRD5A2 52/4885NR4A2 94/4885NR4A1 144/4885 |
| US-20090131510-A1 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ESRRB, ESR2, ESRRA | SRD5A2 52/4885NR4A2 94/4885NR4A1 144/4885 |
| US-20140275284-A1 | DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA | ESR2, GPER1, ESRRA | SRD5A2 104/4885NR4A2 31/4885NR4A1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.