Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 10/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003713 | 0.85 | PRKAA2 (0.41) | PRKAA2FAAHPIK3CAMTORPIK3CD | |
| SCHEMBL402841 | 0.81 | PRKAA2 (0.47) | PRKAA2FAAHPIK3CAMTORPIK3CD | |
| SCHEMBL4008649 | 0.81 | ALDH1A1 (0.40) | FAAH | |
| SCHEMBL4005392 | 0.80 | ALDH1A1 (0.37) | PRKAA2PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4005122 | 0.79 | ALDH1A1 (0.41) | PRKAA2MCHR1 | |
| SCHEMBL403232 | 0.77 | MCHR1 (0.45) | PRKAA2FAAHMCHR1 | |
| SCHEMBL4007633 | 0.75 | CCR3 (0.41) | — | |
| SCHEMBL401983 | 0.74 | ALDH1A1 (0.45) | PRKAA2 | |
| SCHEMBL402321 | 0.73 | PRKAA2 (0.46) | PRKAA2FAAHPIK3CAMTORPIK3CD | |
| SCHEMBL401862 | 0.72 | KDM4E (0.34) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | claimed |