Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 8/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402650 | 0.80 | ACKR3 (0.48) | CCR3SSTR5ACKR3ACHEGALR3 | |
| SCHEMBL4004740 | 0.75 | PRKAA2 (0.41) | — | |
| SCHEMBL436083 | 0.74 | ACKR3 (0.49) | CCR3SSTR5ACKR3ACHEOGA | |
| SCHEMBL4008649 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL19349017 | 0.73 | CCR3 (0.41) | CCR3ACKR3ACHECACNA1G | |
| SCHEMBL18291546 | 0.72 | KMT2A (0.56) | ACKR3 | |
| SCHEMBL398905 | 0.72 | ACKR3 (0.49) | CCR3SSTR5ACKR3ACHEOGA | |
| SCHEMBL401873 | 0.71 | ACKR3 (0.47) | CCR3SSTR5ACKR3ACHEGALR3 | |
| SCHEMBL401862 | 0.71 | KDM4E (0.34) | — | |
| SCHEMBL402696 | 0.71 | ACHE (0.41) | CCR3SSTR5ACKR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |