Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005700 | 1.00 | HSD11B1 (0.67) | HSD11B1RAB9AEPHX2KMT2ATSHR | |
| SCHEMBL612771 | 0.94 | HSD11B1 (0.74) | HSD11B1RAB9AEPHX2KMT2ATSHR | |
| SCHEMBL4447361 | 0.88 | HSD11B1 (0.72) | HSD11B1RAB9AEPHX2KMT2ATSHR | |
| SCHEMBL4010558 | 0.87 | KMT2A (0.60) | HSD11B1RAB9AEPHX2KMT2ATSHR | |
| SCHEMBL4010568 | 0.87 | KMT2A (0.60) | HSD11B1RAB9AEPHX2KMT2ATSHR | |
| SCHEMBL4145741 | 0.87 | HSD11B1 (0.72) | HSD11B1RAB9AEPHX2KMT2ATSHR | |
| SCHEMBL4005031 | 0.86 | HSD11B1 (0.70) | HSD11B1RAB9AEPHX2KMT2AALDH1A1 | |
| SCHEMBL5950609 | 0.86 | HSD11B1 (0.90) | HSD11B1RAB9AEPHX2TSHR | |
| SCHEMBL4010679 | 0.86 | HSD11B1 (0.90) | HSD11B1RAB9AEPHX2TSHR | |
| SCHEMBL4007664 | 0.86 | HSD11B1 (0.90) | HSD11B1RAB9AEPHX2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |