Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007631 | 1.00 | TSHR (0.61) | TSHRKMT2AEPHX2LMNAMEN1 | |
| SCHEMBL4005584 | 0.90 | TSHR (0.67) | TSHRKMT2AEPHX2LMNAMEN1 | |
| SCHEMBL4005572 | 0.90 | TSHR (0.67) | TSHRKMT2AEPHX2LMNAMEN1 | |
| SCHEMBL610914 | 0.89 | TSHR (0.59) | TSHRKMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL610915 | 0.89 | TSHR (0.59) | TSHRKMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL4004277 | 0.86 | ALDH1A1 (0.63) | TSHRKMT2AEPHX2LMNASMN1; SMN2 | |
| SCHEMBL4004270 | 0.86 | ALDH1A1 (0.63) | TSHRKMT2AEPHX2LMNASMN1; SMN2 | |
| SCHEMBL4006092 | 0.81 | TSHR (0.90) | TSHRKMT2AEPHX2LMNAMEN1 | |
| SCHEMBL611584 | 0.81 | ALDH1A1 (0.67) | TSHRKMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL4006097 | 0.81 | TSHR (0.90) | TSHRKMT2AEPHX2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |