Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004270 | 1.00 | ALDH1A1 (0.63) | ALDH1A1LMNAATMEPHX2KDM4E | |
| SCHEMBL611584 | 0.95 | ALDH1A1 (0.67) | ALDH1A1LMNAATMKDM4EKMT2A | |
| SCHEMBL4005679 | 0.87 | EPHX2 (0.76) | ALDH1A1LMNAEPHX2KMT2ASMN1; SMN2 | |
| SCHEMBL4007638 | 0.86 | TSHR (0.61) | LMNAEPHX2KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4007631 | 0.86 | TSHR (0.61) | LMNAEPHX2KMT2AHTTSMN1; SMN2 | |
| SCHEMBL5950721 | 0.81 | RAB9A (0.63) | ALDH1A1LMNAATMEPHX2KMT2A | |
| SCHEMBL4009266 | 0.81 | RAB9A (0.63) | ALDH1A1LMNAATMEPHX2KMT2A | |
| SCHEMBL4009269 | 0.81 | RAB9A (0.63) | ALDH1A1LMNAATMEPHX2KMT2A | |
| SCHEMBL4002522 | 0.81 | EPHX2 (0.78) | ALDH1A1LMNAEPHX2KMT2ATSHR | |
| SCHEMBL4002528 | 0.81 | EPHX2 (0.78) | ALDH1A1LMNAEPHX2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |