Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769478 | 0.91 | HTR1A (0.60) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL13769833 | 0.89 | PDE10A (0.55) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL13770041 | 0.88 | HTR1A (0.58) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL4010829 | 0.87 | HTR1A (0.67) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4013499 | 0.86 | PDE10A (0.53) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL13769760 | 0.85 | HTR1A (0.60) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL4003945 | 0.84 | HTR1A (0.56) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL4011369 | 0.84 | PDE10A (0.52) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL4009199 | 0.83 | PDE10A (0.51) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 | |
| SCHEMBL13770274 | 0.83 | HTR1A (0.61) | HTR1ASLC6A2SLC6A4PDE10ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |