Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769478 | 0.92 | HTR1A (0.60) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL13770041 | 0.91 | HTR1A (0.58) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL4011369 | 0.91 | PDE10A (0.52) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL4009199 | 0.88 | PDE10A (0.51) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL13769760 | 0.87 | HTR1A (0.60) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL4009573 | 0.87 | HTR1A (0.54) | PDE10AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4009060 | 0.86 | HTR1A (0.61) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL4003945 | 0.85 | HTR1A (0.56) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL4014582 | 0.84 | HTR1A (0.62) | PDE10AGPR119LMNAHTR1ASLC6A2 | |
| SCHEMBL13769833 | 0.84 | PDE10A (0.55) | PDE10AGPR119HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |