Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015413 | 0.95 | KDR (0.51) | KDRKDM4EHTTHRH3RORC | |
| SCHEMBL14209512 | 0.80 | KDR (0.60) | KDRKDM4EHTTHRH3RORC | |
| SCHEMBL3865174 | 0.80 | KDR (0.62) | KDRKDM4EHTTHRH3RORC | |
| SCHEMBL4011687 | 0.79 | KDM4E (0.46) | KDRKDM4EHTTRORCMAPT | |
| SCHEMBL13811535 | 0.79 | KDR (0.59) | KDRKDM4EHTTHRH3RORC | |
| Bromide SCHEMBL4014245 | 0.79 | KDR (0.59) | KDRKDM4EHTTHRH3RORC | |
| SCHEMBL4007924 | 0.79 | KDR (0.47) | KDRKDM4EHTTHRH3MAPT | |
| SCHEMBL4009187 | 0.79 | KDR (0.49) | KDRKDM4EHTTHRH3RORC | |
| SCHEMBL4015144 | 0.78 | BCHE (0.48) | KDRKDM4EHTTRORCMAPT | |
| SCHEMBL4014447 | 0.77 | HRH3 (0.48) | KDRKDM4EHTTHRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558567-B1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-06-24 | — | — | EP | claimed |