Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011479 | 0.87 | SMN1; SMN2 (0.43) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4011473 | 0.84 | SMN1; SMN2 (0.43) | KDM4EMEN1KMT2AMAPTHPGD | |
| SCHEMBL4015413 | 0.81 | KDR (0.51) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4010154 | 0.79 | KDR (0.53) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4010419 | 0.79 | KDM4E (0.49) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4011490 | 0.78 | KDR (0.49) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4010377 | 0.77 | KDR (0.55) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4015144 | 0.76 | BCHE (0.48) | KDM4EKDRMAPTHTTHDAC1 | |
| SCHEMBL4015053 | 0.76 | KDR (0.56) | KDM4EKDRMEN1KMT2AMAPT | |
| SCHEMBL4008188 | 0.75 | BRD4 (0.61) | KDM4EKDRMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558567-B1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-06-24 | — | — | EP | claimed |