Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11894104 | 0.82 | POLB (0.77) | POLBALDH1A1GAAGLAPKM | |
| SCHEMBL4721188 | 0.81 | LMNA (0.51) | POLBMAPTGHSRLMNA | |
| SCHEMBL3999218 | 0.81 | POLB (0.70) | POLBALDH1A1GAAGLAPKM | |
| SCHEMBL2470848 | 0.80 | PTGS1 (0.66) | POLBALDH1A1GAATSHRHPGD | |
| SCHEMBL19216966 | 0.80 | POLB (0.73) | POLBALDH1A1GAAGLAPKM | |
| SCHEMBL19216970 | 0.78 | POLB (0.70) | POLBALDH1A1GAAGLAPKM | |
| SCHEMBL22570862 | 0.77 | PTGS1 (0.73) | POLBALDH1A1GAAGLAPKM | |
| SCHEMBL1096257 | 0.76 | POLB (0.67) | POLBALDH1A1GAAMAPTNPSR1 | |
| SCHEMBL5772850 | 0.76 | ALDH1A1 (0.53) | POLBALDH1A1GAAMAPTNPSR1 | |
| SCHEMBL2473817 | 0.75 | LMNA (0.66) | ALDH1A1GAAMAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010784-A1 | NEW COMPOUNDS 955 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009010784-A1 | NEW COMPOUNDS 955 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | WO | disclosed |