Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005873 | 0.95 | CYP1A2 (0.41) | TAAR1CYP1A2LMNAMEN1KMT2A | |
| SCHEMBL4011309 | 0.89 | ROCK2 (0.33) | CYP1A2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4012585 | 0.84 | CHRNA7 (0.34) | CHRNA7 | |
| SCHEMBL397837 | 0.78 | TAAR1 (0.52) | TAAR1CYP1A2LMNAMEN1KMT2A | |
| SCHEMBL402340 | 0.77 | TAAR1 (0.47) | TAAR1CYP1A2LMNAMEN1KMT2A | |
| SCHEMBL4006505 | 0.73 | CHRNA7 (0.36) | MAPTNPC1RAB9APKMCHRNA7 | |
| SCHEMBL5072945 | 0.73 | CHRNA7 (0.36) | MAPTNPC1RAB9APKMCHRNA7 | |
| SCHEMBL403106 | 0.73 | CYP1A2 (0.49) | TAAR1CYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL400879 | 0.73 | CYP1A2 (0.50) | TAAR1CYP1A2MEN1KMT2AHTR1A | |
| SCHEMBL1445958 | 0.72 | CYP1A2 (0.50) | TAAR1CYP1A2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | claimed |