Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | FLT4 | P35916 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011491 | 0.90 | NR1H2 (0.64) | NR1H2NR1H3RXRAFLT1KDR | |
| SCHEMBL4018332 | 0.90 | NR1H2 (0.63) | NR1H2NR1H3RXRA | |
| SCHEMBL4014203 | 0.90 | NR1H2 (0.44) | NR1H2NR1H3RXRAFLT1FLT4 | |
| SCHEMBL4017304 | 0.89 | NR1H2 (0.46) | NR1H2NR1H3RXRAFLT1FLT4 | |
| SCHEMBL4012216 | 0.88 | NR1H2 (0.56) | NR1H2NR1H3RXRAGAAHTR1A | |
| SCHEMBL4012778 | 0.86 | NR1H2 (0.56) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4011085 | 0.86 | NR1H2 (0.60) | NR1H2NR1H3RXRAFLT1FLT4 | |
| SCHEMBL4011525 | 0.86 | NR1H2 (0.62) | NR1H2NR1H3RXRA | |
| SCHEMBL4012811 | 0.84 | NR1H2 (0.53) | NR1H2NR1H3RXRAHTR1AADRA1D | |
| SCHEMBL4013490 | 0.82 | NR1H2 (0.52) | NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |