Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 16/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015147 | 0.92 | NR1H2 (0.50) | NR1H2NR1H3RXRAPTGDR2GPBAR1 | |
| SCHEMBL4011491 | 0.91 | NR1H2 (0.64) | NR1H2NR1H3RXRACDK9 | |
| SCHEMBL4013490 | 0.91 | NR1H2 (0.52) | NR1H2NR1H3RXRAGPBAR1 | |
| SCHEMBL4010720 | 0.84 | NR1H2 (0.52) | NR1H2NR1H3RXRAPTGDR2HTR1A | |
| SCHEMBL4011231 | 0.83 | NR1H2 (0.47) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4012216 | 0.83 | NR1H2 (0.56) | NR1H2NR1H3RXRAPTGDR2HTR1A | |
| SCHEMBL4014203 | 0.82 | NR1H2 (0.44) | NR1H2NR1H3RXRAPTGDR2HTR1A | |
| SCHEMBL4010852 | 0.82 | NR1H2 (0.56) | NR1H2NR1H3RXRACCNT1CDK9 | |
| SCHEMBL4020515 | 0.81 | NR1H2 (0.78) | NR1H2NR1H3RXRA | |
| SCHEMBL4011836 | 0.80 | NR1H2 (0.48) | NR1H2NR1H3RXRAPTGDR2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |