Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014203 | 0.91 | NR1H2 (0.44) | NR1H2NR1H3RXRASCN9AAXL | |
| SCHEMBL4012811 | 0.91 | NR1H2 (0.53) | NR1H2NR1H3RXRAGPBAR1 | |
| SCHEMBL4011231 | 0.91 | NR1H2 (0.47) | NR1H2NR1H3RXRASCN9AAXL | |
| SCHEMBL4011491 | 0.90 | NR1H2 (0.64) | NR1H2NR1H3RXRA | |
| SCHEMBL4018729 | 0.89 | NR1H2 (0.53) | NR1H2NR1H3RXRA | |
| SCHEMBL4009417 | 0.87 | NR1H2 (0.62) | NR1H2NR1H3RXRA | |
| SCHEMBL4015147 | 0.86 | NR1H2 (0.50) | NR1H2NR1H3RXRAAXLMAPK14 | |
| SCHEMBL4011448 | 0.86 | NR1H2 (0.62) | NR1H2NR1H3RXRA | |
| SCHEMBL4010720 | 0.82 | NR1H2 (0.52) | NR1H2NR1H3RXRA | |
| SCHEMBL4010862 | 0.82 | NR1H2 (0.48) | NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |