Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 12/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL735181 | 0.73 | HTR6 (0.43) | OPRL1OPRM1CNR2OPRK1 | |
| SCHEMBL733041 | 0.70 | OPRL1 (0.48) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3144048 | 0.67 | OPRL1 (0.62) | OPRL1OPRM1OPRK1 | |
| SCHEMBL736413 | 0.67 | OPRL1 (0.60) | OPRL1OPRM1OPRK1 | |
| SCHEMBL27494196 | 0.67 | HRH2 (0.45) | HRH2 | |
| SCHEMBL733990 | 0.66 | OPRM1 (0.47) | OPRL1OPRM1OPRK1 | |
| SCHEMBL5166463 | 0.66 | OPRL1 (0.61) | OPRL1OPRM1 | |
| SCHEMBL13650541 | 0.66 | OPRL1 (0.58) | OPRL1OPRM1OPRK1 | |
| SCHEMBL27559062 | 0.65 | HRH2 (0.59) | CNR2HRH2 | |
| SCHEMBL5382074 | 0.65 | OPRL1 (0.68) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |