Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010845 | 1.00 | HSD11B1 (0.49) | HSD11B1TSHREPHX2KMT2ANPC1 | |
| SCHEMBL10123253 | 0.95 | HSD11B1 (0.55) | HSD11B1TSHREPHX2KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL27664845 | 0.91 | HSD11B1 (0.50) | HSD11B1TSHREPHX2KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL612344 | 0.91 | HSD11B1 (0.50) | HSD11B1TSHREPHX2KMT2AMEN1 | |
| SCHEMBL4009624 | 0.89 | HSD11B1 (0.56) | HSD11B1TSHREPHX2KMT2ANPC1 | |
| SCHEMBL4009615 | 0.89 | HSD11B1 (0.56) | HSD11B1TSHREPHX2KMT2ANPC1 | |
| SCHEMBL27684790 | 0.84 | HSD11B1 (0.63) | HSD11B1TSHREPHX2KMT2AMEN1 | |
| SCHEMBL612865 | 0.84 | HSD11B1 (0.63) | HSD11B1TSHREPHX2KMT2AMEN1 | |
| SCHEMBL4007631 | 0.81 | TSHR (0.61) | TSHREPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4007638 | 0.81 | TSHR (0.61) | TSHREPHX2KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |