Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.44 |
| ▸ | JAK3 | P52333 | 11/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | GRK4 | P32298 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.38 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | MUSK | O15146 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005488 | 0.96 | JAK2 (0.47) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4007794 | 0.87 | JAK2 (0.45) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL3950465 | 0.80 | NTRK1 (0.53) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4007185 | 0.79 | JAK2 (0.54) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4007177 | 0.79 | JAK2 (0.54) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL219259 | 0.77 | PAK4 (0.38) | JAK2JAK3AURKAIGF1RLCK | |
| SCHEMBL3034183 | 0.72 | NTRK1 (0.71) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4007014 | 0.71 | IGF1R (0.38) | JAK2JAK3AURKAIGF1RLCK | |
| SCHEMBL4007169 | 0.71 | JAK2 (0.77) | JAK2JAK3NTRK1AURKAIGF1R | |
| SCHEMBL4007173 | 0.71 | JAK2 (0.77) | JAK2JAK3NTRK1AURKAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007753-A2 | 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |