Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.57 |
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012905 | 0.85 | MAOB (0.51) | MAOBIDO1MRGPRX4MPO | |
| SCHEMBL4016083 | 0.82 | MAOB (0.54) | MAOBIDO1NR4A2MPOL3MBTL1 | |
| SCHEMBL4014567 | 0.79 | MPO (0.48) | MAOBIDO1MPOGAAL3MBTL1 | |
| SCHEMBL4012289 | 0.79 | MPO (0.53) | MAOBIDO1NR4A2MPOKDM4E | |
| SCHEMBL3938044 | 0.76 | CYP4F2 (0.47) | MAOBMRGPRX4MPOFFAR1FFAR4 | |
| SCHEMBL28863468 | 0.73 | IDO1 (0.54) | MAOBIDO1NR4A2MRGPRX4ALDH1A1 | |
| SCHEMBL3320586 | 0.73 | MAOB (1.00) | MAOBIDO1NR4A2MRGPRX4GAA | |
| SCHEMBL28267284 | 0.72 | IDO1 (0.70) | MAOBIDO1NR4A2KDM4EALDH1A1 | |
| SCHEMBL23592013 | 0.71 | MAOB (0.62) | MAOBIDO1NR4A2MRGPRX4ALDH1A1 | |
| SCHEMBL31172140 | 0.71 | MAOB (0.76) | MAOBIDO1NR4A2MRGPRX4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |
| US-20080004302-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004302-A1 | Novel Compounds | CYP11B2, CYP11B1, CYP46A1 | MAOB 695/4885IDO1 4109/4885NR4A2 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.