Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011365 | 1.00 | MAPT (0.42) | MAPTHRH4PRKCIKHKMAT2A | |
| SCHEMBL183511 | 0.81 | CHEK2 (0.58) | MAPTHRH4CHEK2TSHRMEN1 | |
| SCHEMBL183512 | 0.81 | CHEK2 (0.58) | MAPTHRH4CHEK2TSHRMEN1 | |
| SCHEMBL184238 | 0.81 | CHEK2 (0.58) | MAPTHRH4CHEK2TSHRMEN1 | |
| SCHEMBL13769265 | 0.81 | MAPT (0.47) | MAPTHRH4PRKCIKHKMAT2A | |
| SCHEMBL183907 | 0.80 | MAT2A (0.49) | HRH4KHKMAT2AHRH3AKT1 | |
| SCHEMBL183906 | 0.80 | MAT2A (0.49) | HRH4KHKMAT2AHRH3AKT1 | |
| SCHEMBL13769465 | 0.80 | CYP1A2 (0.53) | MAPTCHEK2TP53TSHRUSP2 | |
| SCHEMBL14535451 | 0.79 | MAPT (0.42) | MAPTHRH4PRKCIKHKMAT2A | |
| SCHEMBL6111984 | 0.79 | MAPT (0.48) | MAPTHRH4PRKCIMAT2ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |