SCHEMBL4011375

SCHEMBL4011375

CN(C)C(=O)Oc1ccc2c(c1)C=CCN(C)C2CCOc1ccc(F)cc1Cl

nearest known ligand 0.65

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.65
SLC6A4 P31645 2/20 0.65
OXTR P30559 2/20 0.34
AVPR1A P37288 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
PPARG P37231 1/20 0.34
SLC6A9 P48067 1/20 0.34
HRH3 Q9Y5N1 1/20 0.33
PPARA Q07869 1/20 0.33
SCN9A Q15858 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3866090 0.99 ACHE (0.64) ACHESLC6A4OXTRAVPR1ANPC1
SCHEMBL4012427 0.84 ACHE (0.70) ACHESLC6A4NPC1RAB9A
Hydrochloric Acid SCHEMBL3864113 0.83 ACHE (0.69) ACHESLC6A4NPC1RAB9A
SCHEMBL4012422 0.81 ACHE (0.76) ACHESLC6A4RAB9A
SCHEMBL4005576 0.81 ACHE (0.76) ACHESLC6A4RAB9A
SCHEMBL4007712 0.81 ACHE (0.76) ACHESLC6A4RAB9A
Hydrochloric Acid SCHEMBL3864656 0.80 ACHE (0.75) ACHESLC6A4
Hydrochloric Acid SCHEMBL3873753 0.80 ACHE (0.75) ACHESLC6A4
Hydrochloric Acid SCHEMBL3868611 0.80 ACHE (0.75) ACHESLC6A4
SCHEMBL3863710 0.79 ACHE (1.00) ACHESLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7504393-B2 Benzylamine analogues BTG INTERNATIONAL LIMITED (GB) 2009-03-17 US claimed