Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30325618 | 0.83 | HSD11B1 (0.50) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL11048208 | 0.80 | HPGD (0.43) | ALDH1A1CYP3A4TTRKDM4ETSHR | |
| SCHEMBL5981527 | 0.80 | HSD11B1 (0.52) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL285092 | 0.78 | TTR (0.62) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL3002757 | 0.78 | HSD11B1 (0.50) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| Hydrochloric Acid SCHEMBL11627207 | 0.76 | TTR (0.60) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL2866567 | 0.76 | HSD11B1 (0.48) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL11332390 | 0.73 | KDM4E (0.61) | HSD11B1ALDH1A1CYP3A4GAAKDM4E | |
| SCHEMBL1822507 | 0.73 | HSD11B1 (0.46) | HSD11B1ALDH1A1CYP3A4CA1CA2 | |
| SCHEMBL9446723 | 0.73 | HSD11B1 (0.46) | HSD11B1ALDH1A1CYP3A4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953853-B2 | Phospholipase inhbitors; antiinflammatory agents; respiratory system disorders | ALTANA PHARMA AG (DE) | 2005-10-11 | — | — | US | claimed |
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | TAKEDA GMBH (DE) | 2004-04-08 | — | — | US | claimed |
| EP-1362044-A1 | PHTHALAZINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064584-A1 | PHTHALAYINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-22 | — | — | WO | claimed |
| US-7531540-B2 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2009-05-12 | — | — | US | disclosed |
| US-20070129373-A1 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | ALTANA PHARMA AG | 2007-06-07 | — | — | US | disclosed |
| US-7179810-B2 | Such as 2-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-2H-acetamide; phosphodiesterase inhibitors; for treatment of respiratory disorders | ALTANA PHARMA AG (DE) | 2007-02-20 | — | — | US | disclosed |
| US-20060148804-A1 | Pde4 inhibitors for the treatment of neoplasms of lymphoid cells | NYCOMED GMBH (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1587512-A2 | PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS | ALTANA Pharma AG (DE) | 2005-10-26 | — | — | EP | disclosed |
| US-20050234062-A1 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | ALTANA PHARMA AG | 2005-10-20 | — | — | US | disclosed |
| WO-2004062671-A2 | PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS | ALTANA PHARMA AG (DE) | 2004-07-29 | — | — | WO | disclosed |
| EP-1362044-A1 | PHTHALAZINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064584-A1 | PHTHALAYINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-22 | — | — | WO | disclosed |
| EP-0101069-A1 | Phenethanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148804-A1 | Pde4 inhibitors for the treatment of neoplasms of lymphoid cells | PDE4A, PDE4B, PDE4C | HSD11B1 573/4885ALDH1A1 1111/4885CYP3A4 1128/4885 |
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | PDE4A, PDE4B, PDE5A | HSD11B1 66/4885ALDH1A1 376/4885CYP3A4 248/4885 |
| US-20070129373-A1 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | PDE4A, PDE4B, PDE5A | HSD11B1 131/4885ALDH1A1 252/4885CYP3A4 152/4885 |
| US-20050234062-A1 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | PDE4A, PDE4B, PDE5A | HSD11B1 131/4885ALDH1A1 252/4885CYP3A4 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.