Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440 | 0.77 | TSHR (0.50) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| SCHEMBL28758503 | 0.77 | TSHR (0.57) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| Trifluoromethylbenzene SCHEMBL27901681 | 0.76 | ALDH1A1 (0.64) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| SCHEMBL16566613 | 0.76 | ALDH1A1 (0.44) | TSHRALDH1A1KCNN4KIF11 | |
| Trifluoromethylbenzene SCHEMBL18787459 | 0.76 | TSHR (0.82) | TSHRALDH1A1KCNN4KIF11PTPN1 | |
| SCHEMBL5740730 | 0.76 | TAAR1 (0.50) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| SCHEMBL17885859 | 0.75 | ALDH1A1 (0.48) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| Trifluoromethylbenzene SCHEMBL3392949 | 0.75 | TSHR (0.70) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| SCHEMBL3627861 | 0.75 | ALDH1A1 (0.48) | TSHRALDH1A1KCNN4KIF11TAAR1 | |
| Trifluoromethylbenzene SCHEMBL14891620 | 0.75 | ALDH1A1 (0.70) | TSHRALDH1A1KCNN4KIF11PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742931-B1 | DIBENZOFURAN, DIBENZOTHIOPHENE AND FLUORENE DERIVATIVES AS COMPONENTS OF LIQUID-CRYSTALLINE MIXTURES | MERCK PATENT GMBH (DE) | 2014-04-23 | — | — | EP | disclosed |
| US-7514127-B2 | Dibenzofuran derivatives, dibenzothiophene derivatives and fluorene derivatives | MERCK PATENT GMBH (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20070219380-A1 | Dibenzofuran Derivatives, Dibenzothiophene Derivatives and Fluorene Derivatives | MERCK PATENT GMBH (DE) | 2007-09-20 | — | — | US | disclosed |
| EP-1742931-A1 | DIBENZOFURAN DERIVATIVES, DIBENZOTHIOPHENE DERIVATIVES, AND FLUORENE DERIVATIVES | MERCK PATENT GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105772-A1 | DIBENZOFURAN DERIVATIVES, DIBENZOTHIOPHENE DERIVATIVES, AND FLUORENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219380-A1 | Dibenzofuran Derivatives, Dibenzothiophene Derivatives and Fluorene Derivatives | ZYX, F3, YBX1 | TSHR 1688/4885ALDH1A1 680/4885KCNN4 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.