Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120462 | 0.82 | LMNA (0.70) | LMNACYP2C9CYP2C19ALDH1A1KMT2A | |
| SCHEMBL4017204 | 0.71 | KMT2A (0.60) | LMNAALDH1A1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7795503 | 0.70 | SCN3A (0.48) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL612863 | 0.69 | KMT2A (0.77) | LMNAALDH1A1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5915269 | 0.69 | PSEN1 (0.60) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5243682 | 0.68 | KMT2A (0.78) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5243125 | 0.68 | KMT2A (0.78) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5244903 | 0.68 | KMT2A (0.78) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL13651513 | 0.67 | LMNA (0.67) | LMNAALDH1A1EPHX1KMT2AMEN1 | |
| SCHEMBL3710420 | 0.67 | ALDH1A1 (0.71) | LMNAALDH1A1SMN1; SMN2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | claimed |
| WO-2009086426-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION | ARETE THERAPEUTICS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |