Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009346 | 0.88 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL697278 | 0.80 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL697577 | 0.78 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL702854 | 0.75 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL28793807 | 0.73 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL698345 | 0.72 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| Demiditraz SCHEMBL696353 | 0.72 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| Demiditraz SCHEMBL29388955 | 0.72 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| Demiditraz SCHEMBL697081 | 0.72 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| Demiditraz SCHEMBL617479 | 0.72 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CF2RL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-7544706-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-09 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | BACE1 2708/4885ADRA2A 456/4885ADRA2B 317/4885 |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | BACE1 2708/4885ADRA2A 456/4885ADRA2B 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.