Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018060 | 0.77 | MAOA (0.51) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL4013452 | 0.75 | MAOA (0.46) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL4532164 | 0.74 | MAOA (0.37) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL4527581 | 0.74 | PDE10A (0.43) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8272339 | 0.71 | MAOA (0.50) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8272635 | 0.71 | PDE10A (0.56) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL4527577 | 0.70 | PDE10A (0.43) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL7705507 | 0.70 | PDE10A (0.51) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8271339 | 0.69 | PDE10A (0.59) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL4008944 | 0.69 | PDE4B (0.48) | PDE10AMAOANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074106-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | Matrix Laboratories Limited (IN) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008032171-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MATRIX LABORATORIES LTD. (DE) | 2008-03-20 | — | — | WO | disclosed |