SCHEMBL7705507

SCHEMBL7705507

COc1ccc(C2CNC(=O)C2)c2c1oc1ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 3/20 0.51
MAOA P21397 4/20 0.48
MTNR1A P48039 2/20 0.48
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 2/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
PDE4A P27815 9/20 0.46
PDE4B Q07343 5/20 0.46
PDE4C Q08493 5/20 0.46
PDE4D Q08499 5/20 0.46
CYP17A1 P05093 1/20 0.41
CYP19A1 P11511 1/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
CYP3A4 P08684 2/20 0.40
VEGFA P15692 1/20 0.40
CYP1A2 P05177 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8272339 0.88 MAOA (0.50) PDE10AMAOAKDM4EALDH1A1LMNA
SCHEMBL2556256 0.87 PDE4A (0.44) PDE10AMTNR1AKDM4EALDH1A1LMNA
SCHEMBL2559533 0.87 PDE4A (0.44) PDE10AMTNR1AKDM4EALDH1A1LMNA
SCHEMBL7711514 0.86 MTNR1A (0.45) PDE10AMAOAMTNR1AKDM4EALDH1A1
SCHEMBL8271315 0.85 PDE4A (0.46) PDE10AMTNR1AKDM4EALDH1A1LMNA
SCHEMBL7707534 0.85 CYP19A1 (0.48) PDE10AMTNR1AKDM4EALDH1A1LMNA
SCHEMBL2556626 0.84 PDE4A (0.44) PDE10AMTNR1APDE4APDE4BPDE4C
SCHEMBL4018060 0.80 MAOA (0.51) PDE10AMAOAKDM4EALDH1A1LMNA
SCHEMBL8271492 0.80 CSNK2A2 (0.43) PDE10AMTNR1AKDM4EALDH1A1LMNA
SCHEMBL8271335 0.80 PDE4A (0.41) PDE10AMTNR1AKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011132051-A2 TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2011-10-27 WO disclosed
WO-2006011024-A9 NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS LTD (IN) 2006-06-08 WO disclosed
WO-2006011024-A2 NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS LTD. (US) 2006-02-02 WO disclosed