Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020309 | 0.83 | ADORA2B (0.40) | ADORA2AADORA2BKMT2AALDH1A1KDM4E | |
| SCHEMBL4013805 | 0.82 | ADORA2A (0.43) | ADORA2AADORA2BKMT2AALDH1A1KDM4E | |
| SCHEMBL4021124 | 0.79 | AKT2 (0.38) | ADORA2AADORA2BKMT2AALDH1A1KDM4E | |
| SCHEMBL7604058 | 0.77 | PNP (0.51) | ADORA2AADORA2BKMT2ASMN1; SMN2TSHR | |
| SCHEMBL4176128 | 0.73 | ADORA2B (0.62) | ADORA2AADORA2BKMT2AALDH1A1KDM4E | |
| SCHEMBL1945095 | 0.72 | ADORA2B (0.60) | ADORA2AADORA2BADORA3 | |
| SCHEMBL7421517 | 0.70 | PNP (0.46) | KMT2AALDH1A1SMN1; SMN2TSHRGAA | |
| SCHEMBL19211636 | 0.69 | CSNK2A1 (0.42) | ADORA2AADORA2BKMT2AALDH1A1KDM4E | |
| SCHEMBL3554510 | 0.69 | CSNK2A1 (0.43) | ADORA2AADORA2BKMT2AALDH1A1KDM4E | |
| SCHEMBL7421927 | 0.68 | CCNE2 (0.46) | KMT2AKDM4ESMN1; SMN2TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009088518-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | CV THERAPEUTICS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |