Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDE9A | O76083 | 2/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.46 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421517 | 0.91 | PNP (0.46) | PNPADORA3KMT2ATP53GAA | |
| SCHEMBL7421927 | 0.89 | CCNE2 (0.46) | PNPADORA3KMT2ATP53GAA | |
| SCHEMBL7422077 | 0.88 | PNP (0.49) | PNPADORA3KMT2ATP53GAA | |
| SCHEMBL7416425 | 0.85 | PNP (0.47) | PNPKMT2ATP53GAAMAPT | |
| SCHEMBL7420635 | 0.84 | RIPK1 (0.48) | PNPKMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL3110928 | 0.78 | PNP (0.48) | PNPKMT2ATP53GAAMAPT | |
| SCHEMBL3554510 | 0.77 | CSNK2A1 (0.43) | KMT2ATP53GAAMAPTTSHR | |
| SCHEMBL3115741 | 0.77 | ADORA2A (0.58) | PNPKMT2AGAAATMSMN1; SMN2 | |
| SCHEMBL4013558 | 0.77 | ADORA2A (0.42) | PNPADORA3KMT2ATP53GAA | |
| SCHEMBL19211636 | 0.76 | CSNK2A1 (0.42) | KMT2ATP53GAAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | Aventis Pharma S.A. (FR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060824-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA S.A. (FR) | 2001-08-23 | — | — | WO | disclosed |