Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.70 |
| ▸ | USP2 | O75604 | 9/20 | 0.70 |
| ▸ | RECQL | P46063 | 8/20 | 0.70 |
| ▸ | HPGD | P15428 | 8/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.70 |
| ▸ | THRB | P10828 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.70 |
| ▸ | MC4R | P32245 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | RAD52 | P43351 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacycline SCHEMBL21133469 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL13328119 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL5523818 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL4016 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL19771282 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL17430778 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL2614978 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL29376851 | 1.00 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL127703 | 0.99 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD | |
| Methacycline SCHEMBL5445227 | 0.99 | TDP1 (0.70) | TDP1KDM4EUSP2RECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14259 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| WO-2026105164-A1 | NON-AQUEOUS LIQUID FORMULATIONS OF TETRACYCLINE ANTIBIOTICS | ETICO LIFESCIENCES PRIVATE LIMITED (IN) | 2026-05-21 | — | — | WO | claimed |
| EP-4007582-B1 | ANTIBIOTICS IN COMBINATION WITH PHOTODYNAMIC THERAPY FOR USE IN A METHOD OF ENHANCING THE ANTIMICROBIAL ACTION OF SYSTEMICALLY ADMINISTERED ANTIBIOTICS | KOITE HEALTH OY (FI) | 2026-05-20 | — | — | EP | claimed |
| WO-2026086804-A1 | MULTILAYER-REGULATED GENE EDITING SYSTEM AND USE THEREOF | 自如基因科技（深圳）有限公司 | 2026-04-30 | — | — | WO | claimed |
| US-20260108455-A1 | DEVICE FOR SUSTAINED CONTROLLED RELEASE OF A THERAPEUTICALLY ACTIVE SUBSTANCE AND USES THEREOF | HYLOMORPH AG (CH) | 2026-04-23 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| EP-4727558-A1 | NOVEL METHOD EMPLOYING ANTIBIOTICS WITH ACCRETION TO APATITE COATED IMPLANTS PREVENTING BACTERIAL ATTACHMENT AND INFECTION | Moroxite I AB (SE) | 2026-04-22 | — | — | EP | claimed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | claimed |
| EP-4554557-B1 | DEVICE FOR SUSTAINED CONTROLLED RELEASE OF A THERAPEUTICALLY ACTIVE SUBSTANCE AND USES THEREOF | HYLOMORPH AG (CH) | 2026-03-11 | — | — | EP | claimed |
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-0222425-A2 | Brain-specific drug delivery | UNIVERSITY OF FLORIDA (US) | 1987-05-20 | — | — | EP | claimed |
| EP-0218300-A2 | Brain-specific drug delivery | UNIVERSITY OF FLORIDA (US) | 1987-04-15 | — | — | EP | claimed |
| EP-0201057-A2 | Bone targeted inhibitors of carbonic anhydrase | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1986-11-12 | — | — | EP | claimed |
| EP-0046270-B1 | NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | INTERx RESEARCH CORPORATION (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0026746-B1 | COMBINATORY COMPOSITIONS FOR USE IN A METHOD FOR ENHANCING THE ACTIVITY OF ANTIBIOTICS, ANTIBIOTIC PREPARATIONS HAVING ENHANCED ACTIVITY AND PROCESS FOR THEIR PRODUCTION | CIBA-GEIGY AG (CH) | 1985-04-10 | — | — | EP | claimed |
| US-4418060-A | WITH AMINO COMPOUNDS HAVING AT LEAST A TRIS(HYDROXYALKYL)GROUP AND A PRIMARY OR SECONDARY AMINO GROUP | MEDIMPEX GYOGYSZERKULKERESKEDELMI VALLALAT (HU) | 1983-11-29 | — | — | US | claimed |
| US-4414204-A | WITH A MURAMYL-PEPTIDE | CIBA-GEIGY CORPORATION (US) | 1983-11-08 | — | — | US | claimed |
| US-4409209-A | POTENTIATION OF ANTIBIOTICS | CIBA-GEIGY CORPORATION (US) | 1983-10-11 | — | — | US | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| US-3966922-A | TETRACYCLINE, VITAMIN B(2), VANILLIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-06-29 | — | — | US | claimed |