Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL819444 | 0.88 | LMNA (0.62) | HTR6KDM4EUBE2NLMNASMN1; SMN2 | |
| SCHEMBL29737165 | 0.88 | LMNA (0.62) | HTR6KDM4EUBE2NLMNASMN1; SMN2 | |
| SCHEMBL29402217 | 0.87 | KDM4E (0.68) | HTR6KDM4EUBE2NLMNASMN1; SMN2 | |
| SCHEMBL1723740 | 0.87 | KDM4E (0.68) | HTR6KDM4EUBE2NLMNASMN1; SMN2 | |
| SCHEMBL15757279 | 0.86 | HTR6 (0.59) | HTR6CYP3A4CYP2D6KDM4EUBE2N | |
| SCHEMBL17394583 | 0.86 | HTR6 (0.57) | HTR6CYP3A4CYP2D6KDM4EUBE2N | |
| SCHEMBL4012220 | 0.84 | HTR6 (0.61) | HTR6KDM4EUBE2NLMNASMN1; SMN2 | |
| SCHEMBL14637084 | 0.80 | PTGDR2 (0.49) | HTR6CYP3A4CYP2D6KDM4EUBE2N | |
| SCHEMBL30542061 | 0.79 | KDM4E (0.77) | HTR6CYP3A4CYP2D6KDM4EUBE2N | |
| SCHEMBL946340 | 0.79 | KDM4E (0.77) | HTR6CYP3A4CYP2D6KDM4EUBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |