Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821904 | 0.83 | KDM4E (0.51) | KMT2ASMN1; SMN2MEN1LMNAHTT | |
| SCHEMBL5569933 | 0.83 | PTGDR2 (0.45) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 | |
| SCHEMBL989348 | 0.79 | PTGDR2 (0.42) | PTGDR2KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL30152364 | 0.79 | PTGDR2 (0.59) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 | |
| SCHEMBL8712221 | 0.79 | PTGDR2 (0.59) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 | |
| SCHEMBL8712410 | 0.79 | CCR5 (0.42) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 | |
| SCHEMBL8512153 | 0.79 | LMNA (0.40) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 | |
| SCHEMBL8512148 | 0.79 | LMNA (0.40) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 | |
| SCHEMBL2187712 | 0.78 | MAPK1 (0.59) | PTGDR2KMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL128987 | 0.78 | PTGDR2 (0.60) | CYP3A4CYP2D6CYP2C19CYP2C9PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |