Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CFD | P00746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15432930 | 1.00 | KMT2A (0.40) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL15444467 | 0.92 | MEN1 (0.41) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL15432931 | 0.92 | MEN1 (0.41) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL18482365 | 0.91 | MEN1 (0.39) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL44827 | 0.91 | TAS1R3 (0.45) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL44828 | 0.91 | TAS1R3 (0.45) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL18471366 | 0.90 | MEN1 (0.41) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL15432965 | 0.90 | MEN1 (0.41) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL18040380 | 0.90 | KMT2A (0.40) | KMT2AMEN1CFDLMNATAS1R3 | |
| SCHEMBL40206 | 0.88 | TAOK1 (0.39) | KMT2AMEN1CFDLMNATAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |