Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CFD | P00746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44827 | 1.00 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2DHODHKMT2A | |
| SCHEMBL16923856 | 0.92 | TAS1R3 (0.42) | TAS1R3TAS1R1TAS1R2DHODHKMT2A | |
| SCHEMBL6002315 | 0.91 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2DHODHKMT2A | |
| SCHEMBL2732036 | 0.91 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2DHODHKMT2A | |
| SCHEMBL15432930 | 0.91 | KMT2A (0.40) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL40145 | 0.91 | KMT2A (0.40) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL40206 | 0.90 | TAOK1 (0.39) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL45692 | 0.89 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2DHODHKMT2A | |
| SCHEMBL44814 | 0.85 | SLC34A2 (0.35) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL16924043 | 0.83 | DHODH (0.38) | TAS1R3TAS1R1TAS1R2DHODHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |