Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPD | P32754 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | MGMT | P16455 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014596 | 1.00 | POLB (0.43) | POLBMAPTNPC1RAB9AHPGD | |
| SCHEMBL3611368 | 0.89 | POLB (0.49) | POLBMAPTNPC1RAB9AHPGD | |
| SCHEMBL3611364 | 0.89 | POLB (0.49) | POLBMAPTNPC1RAB9AHPGD | |
| SCHEMBL4020681 | 0.83 | POLB (0.45) | POLBMAPTNPC1RAB9AHPGD | |
| SCHEMBL4020683 | 0.83 | POLB (0.45) | POLBMAPTNPC1RAB9AHPGD | |
| SCHEMBL3621324 | 0.76 | LTA4H (0.46) | POLBMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL595211 | 0.73 | MCOLN3 (0.41) | POLBMAPTNPC1RAB9ALMNA | |
| SCHEMBL595210 | 0.73 | MCOLN3 (0.41) | POLBMAPTNPC1RAB9ALMNA | |
| SCHEMBL27750368 | 0.73 | RAB9A (0.45) | POLBMAPTNPC1RAB9AHPGD | |
| SCHEMBL27750250 | 0.72 | MAPT (0.39) | POLBMAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |