Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 13/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193030 | 0.78 | CCR1 (0.62) | CCR1CYP2C19KCNH2 | |
| SCHEMBL3464216 | 0.77 | CCR1 (0.64) | CCR1CYP2C19KCNH2 | |
| SCHEMBL3857556 | 0.76 | CCR1 (0.37) | CCR1CYP2C19KCNH2 | |
| SCHEMBL3637059 | 0.75 | CCR1 (0.49) | CCR1MAPTCYP2C19KCNH2 | |
| SCHEMBL4017083 | 0.75 | CCR1 (0.50) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4016355 | 0.74 | CCR1 (0.45) | CCR1MAPTLMNANPSR1BRD4 | |
| SCHEMBL2353590 | 0.74 | CCR1 (0.57) | CCR1MAPTLMNANPSR1BRD4 | |
| SCHEMBL4306237 | 0.73 | CCR1 (0.42) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4307691 | 0.73 | CCR1 (0.37) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4014907 | 0.73 | CCR1 (0.45) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |