Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353510 | 0.86 | ALDH1A1 (0.47) | CCR1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4021738 | 0.82 | PTGDR (0.45) | CCR1MAPTMAPK1HTTLMNA | |
| SCHEMBL27786565 | 0.79 | CCR1 (0.48) | CCR1MAPTMAPK1HTTLMNA | |
| SCHEMBL6193030 | 0.75 | CCR1 (0.62) | CCR1 | |
| SCHEMBL4020437 | 0.75 | ALDH1A1 (0.46) | CCR1MAPK1HTTLMNAALDH1A1 | |
| SCHEMBL13184089 | 0.75 | CCR1 (0.61) | CCR1MAPTMAPK1HTTLMNA | |
| SCHEMBL2876111 | 0.75 | ADRB1 (0.59) | CCR1MAPTHTTTSHRALDH1A1 | |
| SCHEMBL4014657 | 0.74 | CCR1 (0.43) | CCR1MAPTMAPK1HTTLMNA | |
| SCHEMBL3464221 | 0.74 | CCR1 (0.60) | CCR1MAPTMAPK1HTTLMNA | |
| Hydrochloric Acid SCHEMBL1639434 | 0.74 | ADRB1 (0.58) | CCR1MAPTHTTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |