Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873189 | 0.82 | CCR1 (0.59) | KMT2AMEN1SMN1; SMN2TSHRLMNA | |
| SCHEMBL2943824 | 0.72 | KMT2A (0.61) | KMT2AMEN1POLBSMN1; SMN2TSHR | |
| SCHEMBL2875548 | 0.72 | CCR1 (0.55) | KMT2AMEN1SMN1; SMN2TSHRLMNA | |
| SCHEMBL23732123 | 0.72 | ALDH1A1 (0.54) | KMT2AMEN1POLBSMN1; SMN2TSHR | |
| SCHEMBL14039675 | 0.72 | CCR1 (0.63) | KMT2AMEN1POLBTSHRLMNA | |
| SCHEMBL3958179 | 0.71 | OPRD1 (0.55) | KMT2AMEN1POLBSMN1; SMN2TSHR | |
| SCHEMBL2878654 | 0.69 | CCR1 (0.51) | KMT2AMEN1SMN1; SMN2TSHRLMNA | |
| SCHEMBL8334018 | 0.68 | MAPT (0.49) | KMT2AMEN1POLBSMN1; SMN2TSHR | |
| SCHEMBL22582787 | 0.68 | KMT2A (0.53) | KMT2AMEN1POLBSMN1; SMN2LMNA | |
| SCHEMBL27662975 | 0.68 | CCR1 (0.48) | KMT2AMEN1TSHRMAPTCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |